Eating a curry ‘can help beat dementia’: Ingredient found in turmeric may hold key to repairing brains of people with condition
- Aromatic turmerone encouraged brain stem cells to grow into neurons
- So it could help develop a treatment for neurodegenerative diseases
- But experts urge caution and say research is still at an early stage
Lovers of spicy Indian food could be better equipped
to ward off dementia, research suggests. A compound in the aromatic spice turmeric, a key ingredient in most curries, may hold the key to repairing the brains of people with neurodegenerative diseases such as Alzheimer’s. In laboratory tests, aromatic turmerone promoted the proliferation of brain stem cells and their development into neurons.
Wonder spice: A compound in turmeric, a key ingredient in most curries, may hold the key to repairing the brains of people with neurodegenerative diseases such as Alzheimer’s, according to new research
It could now help scientists develop treatments for conditions in which brain cells are lost, including Alzheimer’s and stroke. Lead researcher Dr Adele Rueger, from the
Institute of Neuroscience and Medicine in Julich, Germany, said: ‘While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine. ‘Our findings on aromatic turmerone take us one step closer to achieving this goal.’
The scientists examined the effect of aromatic turmerone on endogenous neutral stem cells (NSCs) found within adult brains. NSCs go on to develop into neurons, and play an important role in recovery from neurodegenerative diseases. At certain concentrations, the turmeric compound boosted the proliferation of rat foetal NSCs by up to 80 per cent, and increased the speed at which they matured. In living rats, injections of aromatic turmerone led to the expansion of two key brain regions, the subventricular zone (SVZ) and hippocampus. Both are sites in adult mammalian brains where neurogenisis – the growth of new neurons – is known to occur. The findings are published in the online journal Stem Cell Research & Therapy.
Yummy: Turmeric could now help scientists develop treatment for neurodegenerative diseases
Aromatic turmerone is the lesser-studied of two major bio-active compounds in turmeric. The second, curcumin, is a well known anti-inflammatory agent and reputed to have anti-cancer properties. Dr Laura Phipps, from Alzheimer’s Research UK, warned the findings ‘are a long way from determining whether this compound could help fight diseases like Alzheimer’s. ‘It’s not clear whether the results of this research would translate to people, or whether the ability to generate new brain cells in this way would benefit people with Alzheimer’s disease. ‘We’d need to see further studies to fully understand this compound’s effects in the context of a complex disease like Alzheimer’s, and until then people shouldn’t take this as a sign to stock up on supplies of turmeric
for the spice rack. ‘The death of brain cells is a key feature of Alzheimer’s, and investment in research is crucial to understand how this cell death occurs and how to intervene. ‘It takes many years for fundamental research such as this to be translated into new treatments, and for the best chance of success we need to see a range of approaches being taken.’